Neuronal circuits; neurochemistry and principles of network connectivity

About this programme

In the microscope, the landscape of the brain is revealed in all its complexity. In this image from the rat cerebral cortex, antibody-based immunofluorescence has been used to visualize a calcium-binding protein (green) inside neurons (magenta). The support cells of the brain - glia cells - are seen in orange, and cell nuclei are labelled with blue. Image by Paul Williams During the course you will dive into the principles of neuronal connectivity: what are the different means by which neurons can be connected within networks, and how does such coupling affect the membrane properties and activity pattern of the individual cell? How is the performance of a circuit changed by neuromodulation and what are the mechanisms that underlie altered activity in different networks in psychiatric disorders? Moreover, you will be introduced to key techniques used to study neuronal networks, with particular emphasis on molecular methods to manipulate and record activity in the nervous system. Furthermore, you will learn about the use of animals in neuroscience research, including genetic manipulation and ethical and societal aspects of animal experimentation. The course will prepare students for advanced training in neuroscience, but also offers a good basis for work in the pharmaceutical industry. Previous knowledge equivalent to the course Neurochemistry with molecular neurobiology (KN7001) is required in order to follow this course. Part 1; Theory , 10.5 credits Part 2; Laboratory exercises, 1.5 credits Part 3; Literature project , 3 credits